Researchers reveal totally new biological mechanism that underlies cancer
In a landmark study, researchers from the Broad Institute and Massachusetts General Hospital reveal a completely new biological mechanism that underlies cancer. By studying brain tumors that carry...
View ArticleVariations in RANBP1 gene may disrupt brain signaling in neuropsychiatric...
Scientists have identified a gene that appears to play a significant role in raising a person's risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the...
View ArticleUC Berkeley researchers make major improvement in CRISPR-Cas9 gene editing...
University of California, Berkeley, researchers have made a major improvement in CRISPR-Cas9 technology that achieves an unprecedented success rate of 60 percent when replacing a short stretch of DNA...
View ArticleStudy provides evidence for use of inherited genetic markers to improve...
Melanoma is the most dangerous and lethal form of skin cancer. But just how long will a patient survive following the removal of a melanoma tumor? A more definitive answer to that question could come...
View ArticleScientists find how APOBEC protein becomes dangerous when DNA replication...
Cancer is caused by the growth of an abnormal cell which harbours DNA mutations, "copy errors" occurring during the DNA replication process. If these errors do take place quite regularly without having...
View ArticleTwo studies shed new light on nature of tandem DNA repeat arrays
A pair of studies by a team of scientists has shed new light on the nature of a particular type of DNA sequences—tandem DNA repeat arrays—that play important roles in transcription control, genome...
View ArticleNew gene cut-and-paste methods help correct disease-causing mutation in...
For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected.
View ArticleResearchers identify new targets that may help prevent and cure colon cancer
When the audio on your television set or smart phone is too loud, you simply turn down the volume. What if we could do the same for the signaling in our bodies that essentially causes normal cells to...
View ArticleLouLou Foundation, Penn Med set up Program of Excellence to develop...
The London-based LouLou Foundation and the Orphan Disease Center of the Perelman School of Medicine at the University of Pennsylvania have established a Program of Excellence to develop effective...
View ArticleAbnormal breakage of chromosomes in white blood cells triggers aggressive...
A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly...
View ArticleResearchers identify astroglia-mediated mechanism for causing FXS symptoms in...
A study published today in the Journal of Neuroscience led by Yongjie Yang of Tufts University School of Medicine identifies an astroglial trigger mechanism as contributing to symptoms of fragile X...
View ArticleScientists discover X-chromosome-inherited type of osteogenesis imperfecta
Researchers from the University of Zurich and University Children's Hospital Zurich have discovered the first X-chromosome-inherited type of the congenital disease osteogenesis imperfecta, also known...
View ArticleStudy finds microRNA let-7 plays key role in restricting neuroblastoma
Great strides have been made in treating neuroblastoma, the most common cancer in infants and toddlers. However, advanced cases are often fatal, and children who survive often face life-long physical...
View ArticleJAX researchers find precise, reliable way to identify leukemia cells of origin
Every cancer starts with a single cell, and Jackson Laboratory researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads...
View ArticleGender matching may be beneficial to reduce risk of corneal transplant...
A study of patients undergoing corneal transplants indicates that subtle differences between men and women may lead to poorer outcomes for a woman who has received a cornea from a male donor.
View ArticleUC Davis scientists show how cells control DNA synthesis in mitochondria
Aging, neurodegenerative disorders and metabolic disease are all linked to mitochondria, structures within our cells that generate chemical energy and maintain their own DNA. In a fundamental discovery...
View ArticleScientists explore black box of genome biology
Scientists at Florida State University, Baylor College of Medicine and the Broad Institute of Harvard and MIT have broken ground in a little-understood area of human genetics.
View ArticleAlterations in genomic region linked to risk of ASD have distinctive effects...
A new study in Biological Psychiatry reports that variations in 16p11.2, a region of the genome associated with risk of autism spectrum disorder (ASD), have distinct effects on cognition. The findings...
View ArticleStudy reveals insights into survival, surgical interventions for children...
Among children born with the chromosome disorders trisomy 13 or 18 in Ontario, Canada, early death was the most common outcome, but 10 percent to 13 percent survived for 10 years, according to a study...
View ArticleResearchers discover genetic changes in MSH3 gene in patients with hereditary...
The formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated.
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